Description

Ac-Val-Nhme is a protected amino acid derivative, specifically an N-methyl amide of N-acetyl-L-valine. This compound serves as a crucial building block and intermediate in advanced organic synthesis, particularly for the construction of complex peptides and peptidomimetics. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors who require high-purity, specialized reagents for drug discovery and development.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel therapeutic peptides and protease inhibitors.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis (SPPS) to introduce valine derivatives with protected termini.
• Bioconjugation: Serves as a spacer or linker molecule in the design of antibody-drug conjugates (ADCs) and other bioconjugates.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to modulate the pharmacokinetic properties of lead compounds.
• Chemical Biology Probes: Integral for creating labeled peptides and activity-based probes for enzymatic studies.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs producing custom peptides and non-standard amino acids.

Basic Information

Product Name	Ac-Val-Nhme
CAS No.	19701-84-9
Molecular Formula	C8H16N2O2
Molecular Weight	172.23 g/mol
Synonyms	N-Acetyl-L-valine N-methylamide; N-[(2S)-1-(Methylamino)-3-methyl-1-oxobutan-2-yl]acetamide; Ac-Val-NHMe; N-Acetylvaline methylamide; L-Valine, N-acetyl-, N-methylamide; Ac-Val-NHCH3; N-Acetyl-L-valine methyl amide
EINECS	Contact for details

Quality Control

Our Ac-Val-Nhme is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral analysis to confirm enantiomeric integrity, ensuring it meets the stringent requirements for pharmaceutical R&D. A Certificate of Analysis (COA) detailing identity, purity, and specific impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation	[α]²⁰D: -40° to -50° (c=1 in methanol)
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.