Description

D-Glutamic Acid α-Amide Hydrochloride is a high-purity, enantiomerically pure derivative of glutamic acid, specifically the D-isomer of glutamic acid α-amide hydrochloride. This compound is a critical chiral building block and biochemical reagent valued for its role in peptide synthesis and pharmaceutical research. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors who require high-fidelity chiral intermediates for drug development and advanced biochemical studies.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel peptide-based therapeutics and active pharmaceutical ingredients (APIs).
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies and metabolic pathway investigations.
• Peptide Synthesis: Serves as a protected D-glutamine analog in solid-phase and solution-phase peptide synthesis to introduce specific chiral centers.
• Neuroscience Research: Potential application in studying glutamate receptor subtypes and neurotransmission due to its structural similarity to glutamate.
• Reference Standard: Employed as a high-purity analytical standard for quality control and method development in analytical laboratories.
• Food & Flavor Chemistry: Investigated for its potential role in modulating umami taste profiles and as a precursor for flavor compounds.

Basic Information

Product Name	D-Glutamic Acid α-Amide Hydrochloride
CAS No.	19522-40-8
Molecular Formula	C5H11ClN2O3
Molecular Weight	182.60 g/mol
Synonyms	D-Glutamine Hydrochloride; (R)-2-Amino-4-carbamoylbutanoic acid hydrochloride; D-Glutamic acid 5-amide hydrochloride; D-2-Aminoglutaramic acid hydrochloride; H-D-Gln-OH·HCl; D-Glutamine, hydrochloride; (2R)-2-Amino-4-carbamoylbutanoic acid hydrochloride; D-Glutamine HCl
EINECS	243-140-7

Quality Control

Our D-Glutamic Acid α-Amide Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets stringent specifications for pharmaceutical and research applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry conditions to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.