Description

H-Pro-Pro-Pro-Oh CAS NO 19285-44-0 is a high-purity tripeptide derivative, specifically the tri-proline sequence. This compound serves as a critical building block and reference standard in advanced biochemical research and pharmaceutical development. It is essential for researchers and manufacturers in the fields of peptide synthesis, proteomics, and drug discovery who require precise molecular tools.

Application

• Pharmaceutical Intermediate: Used in the synthesis of more complex peptide-based active pharmaceutical ingredients (APIs) and prodrugs.
• Biochemical Research: Serves as a standard or substrate in enzymatic studies, particularly those involving proline-specific enzymes like prolyl oligopeptidase.
• Peptide Library Construction: A key component in solid-phase and solution-phase peptide synthesis for creating libraries used in screening for biological activity.
• Cosmeceutical Development: Investigated for potential use in anti-aging and skin repair formulations due to the role of proline in collagen structure.
• Academic Research: Utilized in universities and research institutes for studying peptide conformation, stability, and structure-activity relationships (SAR).
• Reference Standard: Provides a high-purity benchmark for quality control and analytical method development (e.g., HPLC, MS) in peptide manufacturing.

Basic Information

Product Name	H-Pro-Pro-Pro-Oh
CAS No.	19285-44-0
Molecular Formula	C15H23N3O4
Molecular Weight	309.36 g/mol
Synonyms	Tri-L-proline; L-Prolyl-L-prolyl-L-proline; Pro-Pro-Pro; H-Pro-Pro-Pro-OH; (S)-1-((S)-1-((S)-2-Carboxypyrrolidin-1-yl)-1-oxopropan-2-yl)pyrrolidine-2-carboxylic acid; Proline Homotripeptide; L-Proline Trimer; PPP
EINECS	Contact for details

Quality Control

Our H-Pro-Pro-Pro-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm stereochemical integrity, and identity confirmation via mass spectrometry (MS) and infrared spectroscopy (IR). Certificates of Analysis (COA) with detailed chromatograms are provided to ensure traceability and compliance with your research or cGMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a desiccated environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (all-L isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.