Description

H-Gly-Nle-Oh is a high-purity, protected dipeptide building block used in solid-phase peptide synthesis (SPPS). This compound is critical for researchers and manufacturers requiring precise control over peptide sequence and structure, particularly for incorporating norleucine residues. It is essential for the development of novel therapeutic peptides, biochemical research tools, and high-value fine chemicals. The product is supplied as a high-quality material suitable for demanding applications in pharmaceutical R&D and production.

Application

• Pharmaceutical Intermediates: Key building block for the synthesis of complex therapeutic peptides targeting various diseases.
• Biochemical Research: Used in academic and industrial laboratories to study peptide structure-activity relationships (SAR) and protein interactions.
• Peptide Library Synthesis: Enables the creation of diverse peptide libraries for high-throughput screening in drug discovery programs.
• Analog Development: Facilitates the synthesis of peptide analogs containing the non-natural amino acid norleucine for enhanced metabolic stability or altered properties.
• Fine Chemical Production: Serves as a specialized intermediate in the multi-step synthesis of advanced, high-value chemical entities.

Basic Information

Product Name	H-Gly-Nle-Oh
CAS No.	19257-04-6
Molecular Formula	C8H16N2O3
Molecular Weight	188.23 g/mol
Synonyms	Glycyl-L-norleucine; H-Gly-L-Nle-OH; Gly-Nle; L-Norleucylglycine; N-(2-Aminoacetyl)-L-norleucine; 2-[(2-Aminoacetyl)amino]hexanoic acid; Peptide building block G-Nle; Nle-Gly dipeptide
EINECS	Contact for details

Quality Control

Our H-Gly-Nle-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation via spectroscopic methods. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with the stringent requirements of pharmaceutical and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. For long-term storage, consider desiccated environments.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.