Description

3-Keto-Dihydrosphingosine Hcl is a key synthetic intermediate and biochemical research tool, specifically a hydrochloride salt derivative of a sphingolipid precursor. This compound is critical for studying sphingolipid metabolism and signaling pathways, which are fundamental to cellular processes like apoptosis, proliferation, and stress response. It is primarily utilized by researchers in pharmaceutical R&D, academic institutions, and biotechnology companies focused on metabolic disorders, oncology, and dermatology.

Application

• Biochemical Research: A vital intermediate for the synthesis and study of complex sphingolipids, ceramides, and their derivatives.
• Pharmaceutical Development: Used as a building block in the research and development of novel therapeutics targeting sphingolipid-related pathways for cancer, inflammatory, and neurological diseases.
• Enzyme Inhibition Studies: Serves as a substrate or inhibitor in enzymatic assays to study serine palmitoyltransferase (SPT) and other enzymes in the sphingolipid biosynthesis pathway.
• Cell Signaling Research: Employed to investigate the role of sphingolipid metabolites in cell cycle regulation, differentiation, and programmed cell death (apoptosis).
• Reference Standard: Used as a high-purity analytical standard in HPLC, LC-MS, and NMR for the quantification and identification of sphingolipids in biological samples.
• Cosmeceutical Research: Investigated for its potential role in skin barrier function and the development of topical formulations aimed at improving skin health.

Basic Information

Product Name	3-Keto-Dihydrosphingosine Hcl
CAS No.	18944-28-0
Molecular Formula	C18H38ClNO3
Molecular Weight	351.96 g/mol
Synonyms	3-Ketodihydrosphingosine Hydrochloride; (2S,3R)-2-Amino-3-hydroxyoctadecan-1-one hydrochloride; 3-KDS HCl; Ketosphinganine Hydrochloride; D-erythro-3-Ketosphinganine HCl; 3-Oxodihydrosphingosine HCl; 3-Ketosphingosine HCl; 1-Oxo-2-aminooctadecan-3-ol Hydrochloride
EINECS	Contact for details

Quality Control

Our 3-Keto-Dihydrosphingosine Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a comprehensive Certificate of Analysis (COA) with each shipment, detailing all specifications and test results to ensure traceability and compliance with your research or development protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. Due to its hygroscopic nature, the container should be kept sealed under desiccant or inert atmosphere for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.