Description

n-Methyl-Valine Hydrochloride is a high-purity, non-proteinogenic amino acid derivative essential for advanced peptide synthesis and pharmaceutical research. This compound serves as a critical building block for introducing specific structural modifications, enhancing metabolic stability, and fine-tuning the biological activity of therapeutic peptides. It is primarily utilized by research institutions, pharmaceutical development laboratories, and fine chemical manufacturers engaged in the creation of novel drug candidates and biochemical tools.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel peptide-based pharmaceuticals and protease inhibitors.
• Peptide Chemistry Research: Used to incorporate N-methylated amino acid residues into peptide chains to study conformation-activity relationships and improve pharmacokinetic properties.
• Biochemical Tool Development: Employed in the design and production of enzyme substrates, inhibitors, and probes for biochemical assays.
• Academic & Industrial R&D: Serves as a standard or building block in medicinal chemistry programs focused on metabolic stability and oral bioavailability.
• Fine Chemical Synthesis: Acts as a precursor or intermediate in the multi-step synthesis of complex organic molecules with specific stereochemical requirements.

Basic Information

Product Name	n-Methyl-Valine Hydrochloride
CAS No.	18944-00-8
Molecular Formula	C6H13NO2 • HCl
Molecular Weight	167.63 g/mol (Free base: 131.17 g/mol)
Synonyms	N-Methylvaline hydrochloride; (S)-2-Amino-3-methyl-N-methylbutanoic acid hydrochloride; L-N-Methylvaline HCl; Valine, N-methyl-, hydrochloride; 2-Methylamino-3-methylbutyric acid hydrochloride; (2S)-2-(Methylamino)-3-methylbutanoic acid hydrochloride; N-Me-Val-OH • HCl
EINECS	Contact for details

Quality Control

Our n-Methyl-Valine Hydrochloride is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and a detailed Certificate of Analysis (COA) with each shipment, which includes data for chiral purity, assay, and related substances. Our quality standards are designed to meet the rigorous demands of pharmaceutical R&D and cGMP-guided applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider using a desiccator.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.