Description

L-Tyrosine-Ul-14C is a uniformly carbon-14 labeled isotopologue of the essential amino acid L-Tyrosine, a critical precursor in the biosynthesis of neurotransmitters and hormones. This radiolabeled compound is indispensable for advanced metabolic and pharmacokinetic studies, enabling precise tracking of tyrosine and its derivative pathways in biological systems. It is primarily utilized by research scientists and pharmaceutical developers in drug discovery, biochemical research, and metabolic pathway analysis.

Application

• Tracer Studies in Metabolism: Used to investigate tyrosine metabolism, protein synthesis, and the biosynthesis of catecholamines (dopamine, norepinephrine, epinephrine) and thyroid hormones.
• Drug Metabolism and Pharmacokinetics (DMPK): Essential for ADME (Absorption, Distribution, Metabolism, Excretion) studies to trace the fate of tyrosine-containing compounds or drugs affecting tyrosine pathways.
• Biochemical Pathway Analysis: Employed in enzymatic assays and studies to elucidate specific biochemical pathways and flux analysis in cell cultures or model organisms.
• Proteomics and Protein Turnover Research: Facilitates the study of protein synthesis rates and degradation through incorporation into newly synthesized proteins.
• Neuroscience Research: Critical for tracing the synthesis and release of neurotransmitters derived from tyrosine, aiding research into neurological disorders and psychiatric conditions.
• Agricultural and Plant Biochemistry: Used in studies of amino acid metabolism and transport in plants.

Basic Information

Product Name	L-Tyrosine-Ul-14C
CAS No.	18875-48-4
Molecular Formula	C9H11NO3 (uniformly labeled with 14C)
Molecular Weight	~181.19 g/mol (unlabeled)
Synonyms	(S)-2-Amino-3-(4-hydroxyphenyl)propionic acid-U-14C; L-3-(4-Hydroxyphenyl)alanine-U-14C; L-β-(p-Hydroxyphenyl)alanine-U-14C; Tyrosine-U-14C; 14C-Tyrosine; Uniformly Labeled 14C-Tyrosine; Radioactive L-Tyrosine
EINECS	Contact for details

Quality Control

Our L-Tyrosine-Ul-14C is produced and handled under stringent quality protocols to ensure high chemical, radiochemical, and isomeric purity for sensitive research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing radiochemical purity, specific activity, chemical purity (by HPLC), and solvent composition. We adhere to relevant guidelines for the handling of radioactive materials to ensure product integrity and safety.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive) and strictly light-sensitive; therefore, it must be handled under controlled conditions to maintain stability and prevent decomposition. Allow the vial to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid or solution (as specified)
Identification (IR / NMR)	Conforms to structure
Chemical Purity (HPLC)	≥ 98%
Radiochemical Purity (HPLC)	≥ 97%
Specific Activity	Customizable; typically 50-250 mCi/mmol
Solvent (if supplied as solution)	Specified on COA (e.g., Ethanol/Water, HCl)
Radioactive Concentration	As per customer requirement
Enantiomeric Purity	≥ 99% (L-isomer)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.