Description

H-Ser(Tbu)-Oh is a protected serine derivative, a crucial building block in peptide synthesis. Its primary value lies in providing a reactive carboxylic acid group while protecting the serine side chain hydroxyl, preventing unwanted side reactions during complex peptide assembly. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors who require high-purity intermediates for the development of therapeutic peptides, APIs, and research biochemicals.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled incorporation of serine into peptide chains.
• Solution-Phase Peptide Synthesis: Used in classical coupling strategies for constructing longer or complex peptide sequences.
• Pharmaceutical Intermediate: Serves as a critical raw material in the synthesis of peptide-based Active Pharmaceutical Ingredients (APIs).
• Bioconjugation: Facilitates the site-specific modification of peptides and proteins for drug delivery or diagnostic applications.
• Research & Development: Employed in academic and industrial labs for exploring novel peptide structures and biological activities.
• Combinatorial Chemistry: Used in libraries for high-throughput screening to discover new bioactive compounds.

Basic Information

Product Name	H-Ser(Tbu)-Oh
CAS No.	18822-58-7
Molecular Formula	C7H15NO4
Molecular Weight	177.20 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-L-serine; Boc-L-serine; Boc-Ser-OH; (2S)-2-[(tert-Butoxycarbonyl)amino]-3-hydroxypropanoic acid; L-Serine, N-[(1,1-dimethylethoxy)carbonyl]-; tert-Butyloxycarbonylserine; Boc-Ser; H-Ser(OtBu)-OH (common abbreviation)
EINECS	242-613-6

Quality Control

Our H-Ser(Tbu)-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets the high-purity standards required for peptide synthesis. We provide Certificates of Analysis (COA) with detailed specifications including chiral purity, assay, and impurity profiles. Our quality commitment supports compliance with cGMP guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.5%
Optical Rotation [α]20/D	-3.0° to -5.0° (c=1 in AcOH)
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.