Description

Boc-Ala-D-Glu-Nh2 CAS NO 18814-50-1 is a protected dipeptide building block, specifically an N-Boc derivative of alanine coupled to D-glutamine. This compound is a critical intermediate in the synthesis of complex peptides and peptidomimetics, offering precise stereochemical control and protecting group strategy. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, diagnostic tools, and biochemical probes.

Application

• Pharmaceutical Research & Development: A key chiral intermediate in the solid-phase and solution-phase synthesis of peptide-based drugs, including hormone analogs and enzyme inhibitors.
• Proteomics & Biochemistry: Used to incorporate specific D-amino acid sequences into synthetic peptides for studying protein structure, function, and stability.
• Medicinal Chemistry: Serves as a building block for creating peptide libraries and novel chemical entities in drug discovery programs targeting GPCRs and other biological pathways.
• Bioconjugation: Employed in the preparation of peptide-conjugates for antibody-drug conjugates (ADCs) or diagnostic imaging agents.
• Academic Research: Fundamental reagent for graduate-level and post-doctoral research in organic synthesis, peptide chemistry, and asymmetric synthesis methodologies.

Basic Information

Product Name	Boc-Ala-D-Glu-Nh2
CAS No.	18814-50-1
Molecular Formula	C₁₃H₂₃N₃O₆
Molecular Weight	317.34 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-L-alanyl-D-glutamine; Boc-L-Ala-D-Gln-OH; Boc-Ala-D-Gln; (2R)-4-Amino-2-[[(2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoyl]amino]-4-oxobutanoic acid; tert-Butyloxycarbonyl-L-alanyl-D-glutamine; Boc-Ala-Gln(D); N-Boc-L-alanyl-D-glutamine; Boc-L-Ala-D-Glu-NH₂
EINECS	Contact for details

Quality Control

Our Boc-Ala-D-Glu-Nh2 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and NMR for structural confirmation, to ensure it meets the high standards required for research and pharmaceutical applications. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.