Description

Boc-Glu-Nh2 is a protected derivative of glutamine, a crucial amino acid building block. This compound is essential for the synthesis of peptides and peptidomimetics, providing a critical handle for orthogonal deprotection strategies in complex organic and medicinal chemistry. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for developing novel therapeutic agents and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the controlled assembly of peptide chains in drug discovery and research.
• Solution-Phase Peptide Chemistry: Used in the synthesis of custom peptides, peptide hormones, and enzyme substrates.
• Pharmaceutical Intermediates: Serves as a vital building block in the production of active pharmaceutical ingredients (APIs) and prodrugs.
• Bioconjugation: Employed in the modification of proteins, antibodies, and other biomolecules for diagnostic and therapeutic applications.
• Biochemical Research: Used in studies of enzyme mechanisms, receptor-ligand interactions, and metabolic pathways.
• Combinatorial Chemistry: A valuable reagent for generating diverse chemical libraries for high-throughput screening.

Basic Information

Product Name	Boc-Glu-Nh2
CAS No.	18800-74-3
Molecular Formula	C₁₀H₁₈N₂O₅
Molecular Weight	246.26 g/mol
Synonyms	Nα-Boc-L-glutamine; Nα-(tert-Butoxycarbonyl)-L-glutamine; Boc-L-Gln-OH; (2S)-2-[(tert-Butoxycarbonyl)amino]-4-carbamoylbutanoic acid; Boc-Glutamine; Boc-Gln; N-Boc-L-glutamine; tert-Butyloxycarbonyl-L-glutamine
EINECS	Contact for details

Quality Control

Our Boc-Glu-Nh2 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic identification. Certificates of Analysis (COA) detailing purity, specific rotation, and impurity profiles are available upon request to ensure it meets the stringent requirements for pharmaceutical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a low-humidity environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation [α]₂₀D	-15.0° to -18.0° (c=1 in AcOH)
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.