Description

2,4-Diaminopyrimidine-5-Carboxylic Acid is a high-purity heterocyclic building block of significant importance in advanced organic synthesis. This compound matters as a versatile precursor for constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and specialty fine chemicals. Pharmaceutical research and development (R&D) laboratories, agrochemical manufacturers, and specialty chemical producers need this material for creating novel compounds with targeted biological activity.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of dihydrofolate reductase (DHFR) inhibitors, antifolate drugs, and other therapeutic agents.
• Agrochemical Research: Used in the development of novel herbicides and fungicides, leveraging its pyrimidine core structure.
• Chemical Biology & Proteomics: Serves as a scaffold for designing enzyme inhibitors, molecular probes, and tool compounds for biological studies.
• Fine Chemical Synthesis: Employed in the preparation of complex heterocycles, ligands for catalysis, and advanced materials precursors.
• Academic & Industrial R&D: A valuable starting material for medicinal chemistry programs and novel compound library generation in contract research organizations (CROs).

Basic Information

Product Name	2,4-Diaminopyrimidine-5-Carboxylic Acid
CAS No.	18588-61-9
Molecular Formula	C5H6N4O2
Molecular Weight	154.13 g/mol
Synonyms	5-Carboxy-2,4-diaminopyrimidine; 2,4-Diamino-5-pyrimidinecarboxylic acid; 5-Pyrimidinecarboxylic acid, 2,4-diamino-; 2,4-Diaminopyrimidine-5-carboxylic acid; 18588-61-9; NSC 51128; CCRIS 6056; AI3-28400; 2,4-Diamino-5-carboxypyrimidine
EINECS	Contact for details

Quality Control

Our 2,4-Diaminopyrimidine-5-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure it meets the high-purity standards required for pharmaceutical and research applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to ensure full traceability and compliance with your internal quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). The product may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.