Description

4-Chloro-2-Tertbutylpyrimidine is a versatile halogenated pyrimidine derivative, a key building block in advanced organic synthesis. Its value lies in providing a reactive chloro-substituent adjacent to a sterically hindered tert-butyl group, enabling selective functionalization for complex molecule construction. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical sectors, particularly for developing active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: A crucial synthon for the synthesis of active pharmaceutical ingredients (APIs), especially in antiviral, anticancer, and central nervous system (CNS) drug discovery programs.
• Agrochemical Synthesis: Serves as a core structure for developing novel herbicides, fungicides, and insecticides, leveraging the pyrimidine scaffold's bioactivity.
• Ligand & Catalyst Development: Used in the preparation of specialized ligands for transition metal catalysis and organocatalysts due to its tunable electronic properties.
• Material Science Research: Acts as a monomer or precursor for creating functionalized polymers, liquid crystals, and organic electronic materials.
• Custom Synthesis & Contract Manufacturing: A high-purity starting material for custom synthesis services and scale-up production under cGMP conditions.
• Academic & R&D Laboratories: Employed in methodological studies and as a reference standard in organic chemistry research.

Basic Information

Product Name	4-Chloro-2-Tertbutylpyrimidine
CAS No.	18436-67-4
Molecular Formula	C8H11ClN2
Molecular Weight	170.64 g/mol
Synonyms	2-(tert-Butyl)-4-chloropyrimidine; 4-Chloro-2-(1,1-dimethylethyl)pyrimidine; 4-Chloro-2-tert-butylpyrimidine; Pyrimidine, 4-chloro-2-(1,1-dimethylethyl)-; 2-tert-Butyl-4-chloropyrimidine
EINECS	Contact for details

Quality Control

Our 4-Chloro-2-Tertbutylpyrimidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) for every shipment. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring reliability for your most critical synthesis steps.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.