Description

2-Fluoro-4-Hydroxyaniline, Hcl is an important halogenated aniline derivative, specifically the hydrochloride salt of 4-amino-3-fluorophenol. This compound serves as a versatile and high-value pharmaceutical intermediate and organic building block for advanced synthesis. It is primarily utilized in the research and development of active pharmaceutical ingredients (APIs), agrochemicals, and specialty dyes. Its unique structure, featuring both an amine and a phenol group ortho to a fluorine atom, makes it a critical precursor for creating complex molecules with targeted biological activity.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides where the fluorine atom enhances bioactivity and stability.
• Dye and Pigment Manufacturing: Serves as a precursor for high-performance, light-fast azo dyes and specialty pigments.
• Liquid Crystal & OLED Materials: A valuable intermediate in the synthesis of fluorinated compounds for electronic display technologies.
• Cross-Coupling Reactions: Acts as a substrate in Suzuki, Buchwald-Hartwig, and other palladium-catalyzed coupling reactions to create biaryl structures.
• Chemical Research & Development: Employed in academic and industrial R&D for exploring new synthetic methodologies and material science applications.

Basic Information

Product Name	2-Fluoro-4-Hydroxyaniline, Hcl
CAS No.	18266-53-0
Molecular Formula	C6H7ClFNO
Molecular Weight	163.58 g/mol
Synonyms	4-Amino-3-fluorophenol hydrochloride; 3-Fluoro-4-aminophenol hydrochloride; 2-Fluoro-4-aminophenol HCl; 1-Amino-2-fluoro-4-hydroxybenzene hydrochloride; 3-Fluoro-4-hydroxyaniline hydrochloride; 2-Fluoro-1-hydroxy-4-aminobenzene hydrochloride; 4-Hydroxy-2-fluoroaniline hydrochloride; Benzenamine, 4-amino-3-fluoro-, hydrochloride
EINECS	Contact for details

Quality Control

Our 2-Fluoro-4-Hydroxyaniline, Hcl is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for demanding pharmaceutical and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals (as Pb)	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.