Description

Pyrimidine, 4,6-Difluoro-2,5-Dimethyl- (8Ci) is a fluorinated pyrimidine derivative, a high-value chemical intermediate prized for its unique molecular structure. This compound matters for its role as a critical building block in the synthesis of advanced pharmaceuticals and agrochemicals, enabling the introduction of fluorine atoms to enhance biological activity and metabolic stability. It is primarily needed by research and development chemists in the pharmaceutical industry for creating novel active pharmaceutical ingredients (APIs), as well as by agrochemical manufacturers developing next-generation crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon in the research and production of fluorinated drug candidates, particularly in oncology, antiviral, and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the difluoromethylpyrimidine moiety contributes to efficacy and environmental profile.
• Material Science Research: Serves as a precursor for specialty chemicals and functional materials, including liquid crystals and organic electronic components.
• Organic Synthesis Building Block: Employed in academic and industrial R&D for constructing complex heterocyclic compounds via cross-coupling and other advanced reactions.
• Fluorine Chemistry Studies: Utilized as a standard or reagent in methodological development for introducing fluorine into organic molecules.

Basic Information

Product Name	Pyrimidine, 4,6-Difluoro-2,5-Dimethyl- (8Ci)
CAS No.	18260-63-4
Molecular Formula	C6H6F2N2
Molecular Weight	144.12 g/mol
Synonyms	4,6-Difluoro-2,5-dimethylpyrimidine; 2,5-Dimethyl-4,6-difluoropyrimidine; 4,6-Difluoro-2,5-dimethyl-1,3-diazine; NSC 339063; AI3-52266; CCRIS 9385; 1,3-Diazine, 4,6-difluoro-2,5-dimethyl-
EINECS	Contact for details

Quality Control

Our 4,6-Difluoro-2,5-dimethylpyrimidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing identity, purity, and impurity profiles. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents, strong acids, and strong bases. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.