Description

2,4,6-Trifluoro-5-Methylpyrimidine is a versatile fluorinated heterocyclic building block essential for advanced organic synthesis. Its unique trifluoromethylpyrimidine structure makes it a critical intermediate for introducing fluorine atoms into complex molecules, significantly altering their physicochemical properties. This compound is primarily sought after by pharmaceutical and agrochemical R&D teams for the development of novel active ingredients, where its incorporation can enhance metabolic stability, bioavailability, and lipophilicity.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of fluorinated drug candidates, particularly for antiviral, anticancer, and central nervous system (CNS) targeted therapies.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where fluorine atoms improve efficacy and environmental profile.
• Material Science Precursor: Serves as a building block for advanced materials, including liquid crystals, organic semiconductors, and specialty polymers.
• Chemical Research & Development: Employed in academic and industrial labs for method development, catalysis studies, and exploring new fluorination reactions.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects requiring specific fluorinated pyrimidine scaffolds.

Basic Information

Product Name	2,4,6-Trifluoro-5-Methylpyrimidine
CAS No.	18260-60-1
Molecular Formula	C5H3F3N2
Molecular Weight	148.08 g/mol
Synonyms	5-Methyl-2,4,6-trifluoropyrimidine; 2,4,6-Trifluoro-5-methylpyrimidine; 5-Methyl-2,4,6-trifluoro-1,3-diazine; Trifluoro-5-methylpyrimidine; 18260-60-1; 5-Methyl-2,4,6-trifluoropyrimidine; 2,4,6-Trifluor-5-methylpyrimidin (German)
EINECS	Contact for details

Quality Control

Our 2,4,6-Trifluoro-5-Methylpyrimidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC/HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and industrial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use and stored away from heat sources and open flame. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0% (Standard Grade)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.