Description

Angiotensin II, Ala(8)- is a synthetic peptide analog of the endogenous vasoconstrictor hormone Angiotensin II, specifically modified by alanine substitution at the eighth position. This structural modification is critical for research into the renin-angiotensin system (RAS), receptor specificity, and metabolic pathways. It serves as an essential biochemical tool for pharmaceutical R&D, academic research, and diagnostic assay development targeting cardiovascular and renal physiology.

Application

• Biochemical Research: Used as a reference standard and active agent in studies of the renin-angiotensin-aldosterone system (RAAS), receptor binding assays, and signal transduction pathways.
• Pharmaceutical Development: A key intermediate and pharmacological probe in the discovery and testing of novel antihypertensive drugs, ACE inhibitors, and angiotensin receptor blockers (ARBs).
• Diagnostic Reagents: Employed in the development and calibration of immunoassays (e.g., ELISA, RIA) for measuring angiotensin peptides in biological samples.
• Cell Culture & Physiology Studies: Applied in vitro to investigate vascular smooth muscle contraction, aldosterone secretion, and cellular responses mediated by AT1 and AT2 receptors.
• Metabolic Studies: Utilized to explore the enzymatic degradation pathways of angiotensin peptides by aminopeptidases and other proteases.

Basic Information

Product Name	Angiotensin II, Ala(8)-
CAS No.	18197-01-8
Molecular Formula	C₄₉H₆₉N₁₃O₁₂
Molecular Weight	1032.2 g/mol
Synonyms	[Ala⁸]-Angiotensin II; Asp-Arg-Val-Tyr-Ile-His-Ala-Phe; Angiotensin II (1-8) heptapeptide Ala⁸ analog; Saralasin acetate (related analog); H-Asp-Arg-Val-Tyr-Ile-His-Ala-Phe-OH; DRVYIHAF; UNII-4Y8UXI0G6K
EINECS	Contact for details

Quality Control

Our Angiotensin II, Ala(8)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, MS for identity confirmation, and amino acid analysis. Certificates of Analysis (COA) with detailed chromatographic data are provided to ensure the material meets the stringent requirements for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. The product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥95%
Single Impurity (HPLC)	≤1.0%
Water Content (KF)	≤5.0%
Peptide Content	≥80%
Solubility	Soluble in water, acetic acid, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.