Description

(D-Ser1)-Acth (1-24) (Human, Bovine, Rat) CAS NO 18067-65-7 is a synthetic peptide fragment of adrenocorticotropic hormone (ACTH), specifically the first 24 amino acids with a D-serine substitution at position 1. This modification enhances its metabolic stability and biological activity, making it a critical tool for research and development in endocrinology. It is essential for scientists and manufacturers in the pharmaceutical and biotechnology sectors who require high-purity, well-characterized peptides for preclinical studies, bioassay standards, and diagnostic applications.

Application

• Endocrine Research: Used as a stable, potent agonist for studying ACTH receptor (MC2R) signaling pathways and adrenal cortex function.
• Pharmaceutical Reference Standard: Serves as a certified reference material for the quality control and assay validation of related therapeutic peptides.
• Bioassay & Diagnostic Development: Employed in the development and calibration of in vitro bioassays and diagnostic kits for assessing adrenal gland activity.
• Neuroscience Studies: Investigated for its potential neuromodulatory and behavioral effects in preclinical models.
• Biochemical Tool: Utilized in structure-activity relationship (SAR) studies to understand peptide hormone interactions and design novel analogs.

Basic Information

Product Name	(D-Ser1)-Acth (1-24) (Human, Bovine, Rat)
CAS No.	18067-65-7
Molecular Formula	C₁₃₆H₂₁₀N₄₀O₃₉S
Molecular Weight	2933.4 g/mol
Synonyms	Cosyntropin; Tetracosactide; Tetracosactrin; Synacthen; Cortrosyn; (D-Ser¹)-ACTH (1-24); Adrenocorticotropic Hormone Fragment 1-24 (D-Serine); ACTH (1-24), (D-Ser¹)-
EINECS	Contact for details

Quality Control

Our (D-Ser1)-Acth (1-24) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). We provide full traceability and Certificates of Analysis (COA) detailing purity, peptide content, and impurity profiles to ensure compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). For long-term storage, desiccate. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0% (by AAA)
Single Impurity (HPLC)	≤ 2.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.