Description

D-Histidine Methyl Ester is a chiral, non-proteinogenic amino acid derivative of significant interest in advanced chemical synthesis. This compound matters as a crucial chiral building block and intermediate for the development of pharmaceuticals, bioactive peptides, and fine chemicals. Industries that need it include pharmaceutical R&D for drug discovery, biotechnology for peptide synthesis, and academic research for studying enzyme mechanisms and chiral catalysis.

Application

• Pharmaceutical Intermediate: Key chiral precursor in the synthesis of novel active pharmaceutical ingredients (APIs) and peptidomimetics.
• Peptide Synthesis: Used as a protected amino acid derivative in solid-phase and solution-phase peptide chemistry.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies and for probing histidine-related biological pathways.
• Asymmetric Catalysis: Employed as a ligand or chiral auxiliary in the development of stereoselective synthetic methodologies.
• Reference Standard: Utilized as a high-purity analytical standard in quality control laboratories for method development and validation.
• Fine Chemical Production: Intermediate for the manufacture of specialty chemicals, flavors, and fragrances requiring specific stereochemistry.

Basic Information

Product Name	D-Histidine Methyl Ester
CAS No.	17720-12-6
Molecular Formula	C7H11N3O2
Molecular Weight	169.18 g/mol
Synonyms	D-Histidine Methyl Ester; (R)-2-Amino-3-(1H-imidazol-4-yl)propanoic acid methyl ester; Methyl D-histidinate; D-Histidine O-methyl ester; (R)-Histidine methyl ester; Methyl (R)-2-amino-3-(1H-imidazol-4-yl)propanoate; (2R)-2-Amino-3-(1H-imidazol-5-yl)propanoic acid methyl ester
EINECS	Contact for details

Quality Control

Our D-Histidine Methyl Ester is produced under strict quality management systems to ensure batch-to-batch consistency and high purity. The product undergoes rigorous analytical testing, including chiral purity verification by HPLC, to meet the stringent requirements of research and development applications. Certificates of Analysis (COA) detailing identity, purity, and chiral excess are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.