Description

5-Iodoorotic Acid is a halogenated derivative of orotic acid, serving as a key synthetic intermediate in organic and medicinal chemistry. Its value lies in its role as a versatile building block for the preparation of more complex heterocyclic compounds and nucleoside analogs. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents and biochemical probes.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of iodinated pyrimidine derivatives and potential drug candidates.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies related to pyrimidine metabolism.
• Nucleoside Analog Synthesis: Serves as a starting material for creating modified nucleosides with potential antiviral or anticancer activity.
• Organic Synthesis Building Block: Employed in cross-coupling reactions and other transformations to introduce the iodoorotate moiety into target molecules.
• Labeling and Tracer Studies: The iodine atom provides a handle for radiolabeling (with I-125) for use in diagnostic imaging or metabolic pathway tracing.

Basic Information

Product Name	5-Iodoorotic Acid
CAS No.	17687-22-8
Molecular Formula	C5H3IN2O4
Molecular Weight	281.99 g/mol
Synonyms	5-Iodo-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid; 5-Iodoorotic acid monohydrate; 5-Iodouracil-6-carboxylic acid; 6-Carboxy-5-iodouracil; 1,2,3,6-Tetrahydro-5-iodo-2,6-dioxo-4-pyrimidinecarboxylic acid
EINECS	Contact for details

Quality Control

Our 5-Iodoorotic Acid is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for research and development applications. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 3.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.