Description

4,5,6-Trifluoropyrimidine is a versatile fluorinated heterocyclic building block essential for advanced organic synthesis. Its value lies in the unique reactivity imparted by the trifluoromethylated pyrimidine core, enabling the precise introduction of fluorine atoms to modulate the physicochemical properties of target molecules. This high-purity intermediate is critically needed by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in antiviral, anticancer, and CNS-targeted drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where fluorination enhances bioactivity and environmental stability.
• Material Science Research: Serves as a precursor for novel fluorinated polymers, liquid crystals, and electronic materials requiring specific dielectric properties.
• Chemical Biology & Proteomics: Employed as a tagging or labeling reagent in probe development for studying biological systems.
• Cross-Coupling Reactions: Acts as a substrate in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to construct complex molecular architectures.
• Nucleoside & Nucleotide Analog Synthesis: Used in the modification of nucleosides to create potential therapeutic agents.

Basic Information

Product Name	4,5,6-Trifluoropyrimidine
CAS No.	17573-78-3
Molecular Formula	C4HF3N2
Molecular Weight	134.06 g/mol
Synonyms	Pyrimidine, 4,5,6-trifluoro-; 4,5,6-Trifluoropyrimidine; 1,3-Diazine, 4,5,6-trifluoro-; Trifluoropyrimidine; 4,5,6-Trifluoro-1,3-diazine; NSC 406924; AI3-52220; BRN 1167185
EINECS	Contact for details

Quality Control

Our 4,5,6-Trifluoropyrimidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use to prevent evaporation and potential concentration changes. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.