Description

(R)-1-((5-Amino-6-Chloropyrimidin-4-Yl)Amino)Propan-2-Ol CAS NO 17435-30-2 is a high-purity chiral intermediate featuring a pyrimidine core with amino and chloro substituents. This compound is critical for the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs), particularly in antiviral and oncology research. It is primarily utilized by pharmaceutical R&D departments and fine chemical manufacturers requiring a reliable, high-quality building block for complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the development of nucleoside analog antiviral drugs and targeted cancer therapies.
• Antiviral Drug Synthesis: Used in research and production pathways for novel antiviral agents, leveraging its pyrimidine scaffold.
• Oncology Research: Serves as a precursor in the creation of small molecule inhibitors and other therapeutic candidates for cancer treatment.
• Asymmetric Synthesis: Employed in stereoselective chemical reactions to introduce the (R)-propan-2-ol amine moiety into complex molecules.
• Biochemical Research: Utilized as a standard or reagent in enzymatic studies and biochemical assays involving nucleotide metabolism.
• Fine Chemical Production: An essential building block for contract research organizations (CROs) and CDMOs specializing in custom synthesis.

Basic Information

Product Name	(R)-1-((5-Amino-6-Chloropyrimidin-4-Yl)Amino)Propan-2-Ol
CAS No.	17435-30-2
Molecular Formula	C7H10ClN5O
Molecular Weight	215.64 g/mol
Synonyms	(R)-1-((5-Amino-6-chloro-4-pyrimidinyl)amino)-2-propanol; (R)-1-[(5-Amino-6-chloropyrimidin-4-yl)amino]propan-2-ol; 6-Chloro-N4-[(1R)-1-hydroxypropan-2-yl]pyrimidine-4,5-diamine; (R)-Isoproterenol intermediate; 4-Amino-6-chloro-5-[[(1R)-1-hydroxy-2-propanyl]amino]pyrimidine; 17435-30-2; (R)-enantiomer of 1-((5-Amino-6-Chloropyrimidin-4-Yl)Amino)Propan-2-Ol
EINECS	Contact for details

Quality Control

Our (R)-1-((5-Amino-6-Chloropyrimidin-4-Yl)Amino)Propan-2-Ol is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Production adheres to cGMP guidelines where applicable, and each lot is supported by a comprehensive Certificate of Analysis (COA). The COA includes data for chiral purity, chemical purity (HPLC), and identification, providing full traceability and compliance for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.