Description

2'-(Trifluoromethyl)Acetophenone CAS NO 17408-14-9 is a versatile fluorinated aromatic ketone, a key building block in advanced organic synthesis. Its trifluoromethyl group imparts unique electronic and steric properties, making it invaluable for modifying the biological activity and physicochemical characteristics of target molecules. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical sectors developing next-generation active ingredients.

Application

• Pharmaceutical Intermediate: A critical synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in CNS and anti-inflammatory drug candidates.
• Agrochemical Synthesis: Used in the production of advanced herbicides and pesticides, where the CF₃ group enhances lipophilicity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated compounds used in electronic display technologies and organic light-emitting diodes.
• Advanced Polymer Chemistry: Incorporated as a monomer or modifier to create specialty polymers with enhanced chemical resistance and thermal stability.
• Organic Synthesis & Catalysis: A valuable reagent in cross-coupling reactions and as a ligand precursor in transition metal catalysis.
• Fluorine Chemistry Research: A fundamental compound for studying structure-activity relationships (SAR) in medicinal and materials chemistry.

Basic Information

Product Name	2'-(Trifluoromethyl)Acetophenone
CAS No.	17408-14-9
Molecular Formula	C₉H₇F₃O
Molecular Weight	188.15 g/mol
Synonyms	2-(Trifluoromethyl)acetophenone; 1-[2-(Trifluoromethyl)phenyl]ethanone; α,α,α-Trifluoro-o-acetophenone; 2-Acetylbenzotrifluoride; o-(Trifluoromethyl)acetophenone; 2-Trifluoromethylacetophenone; 2'-Trifluoromethylacetophenone; 1-(2-Trifluoromethylphenyl)ethan-1-one
EINECS	Contact for details

Quality Control

Our 2'-(Trifluoromethyl)Acetophenone is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and identity. We provide full traceability and detailed Certificates of Analysis (COA) with each shipment, confirming compliance with customer specifications and industry standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and bases. Recommended storage temperature is 2-8°C for long-term stability. The compound is compatible with most organic solvents but should be kept under an inert atmosphere for extended periods to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20/D)	1.460 - 1.470
Density (20°C)	1.28 - 1.32 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.