Description

L-Kynurenine Sulfate is a high-purity, crystalline salt form of the essential tryptophan metabolite L-Kynurenine. This compound serves as a critical biochemical precursor and research standard in the study of the kynurenine pathway, which is central to neurobiology, immunology, and metabolic processes. It is primarily utilized by research institutions, pharmaceutical developers, and diagnostic manufacturers for applications in neuroscience, oncology, and immunomodulation research. Our product is supplied to meet the stringent demands of advanced life science and pharmaceutical development.

Application

• Biochemical Research Standard: Used as a certified reference material for quantifying kynurenine pathway metabolites in biological samples via HPLC, LC-MS, or ELISA.
• Neuroscience & Neuropharmacology: A key intermediate for studying neuroactive metabolites like quinolinic acid and kynurenic acid, relevant to neurodegenerative diseases, depression, and schizophrenia.
• Immunology & Cancer Research: Investigated for its role in immune tolerance and tumor immunology, as the kynurenine pathway is implicated in T-cell regulation and tumor microenvironment modulation.
• Enzymology Studies: Serves as a substrate for enzymes such as kynurenine 3-monooxygenase (KMO) and kynureninase in kinetic and inhibition assays.
• Diagnostic Kit Development: Employed in the manufacturing of calibrators and controls for clinical diagnostic assays measuring tryptophan metabolism disorders.
• Precursor for Synthesis: Used in the chemical or enzymatic synthesis of more complex neuroactive compounds and research probes within the kynurenine pathway.

Basic Information

Product Name	L-Kynurenine Sulfate
CAS No.	17268-44-9
Molecular Formula	C10H12N2O4 • H2SO4
Molecular Weight	304.28 g/mol (Free base: 208.21 g/mol)
Synonyms	L-Kynurenine Sulphate; (S)-2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid sulfate; Kynurenine Sulfate; Kynurenine Acid Sulfate; H-Kyn-OH • H2SO4; (S)-Kynurenine Sulfate; 3-Anthraniloyl-L-alanine Sulfate; L-2-Amino-4-(2-aminobenzoyl)butyric acid sulfate
EINECS	Contact for details

Quality Control

Every batch of L-Kynurenine Sulfate is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. We adhere to high standards suitable for research and development applications. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing key parameters such as assay, chiral purity, and impurity profile. Specifications can be aligned with customer requirements for specific research or development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. The product is hygroscopic (moisture-sensitive) and should be handled in a low-humidity environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation	[α]D20: Specific range provided on COA
Chiral Purity (HPLC)	≥ 99.0% (L-Isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.