Description

Z-His-Tyr-Oh is a protected dipeptide derivative, specifically the C-terminal carboxylic acid of histidine and tyrosine. This compound serves as a crucial building block (amino acid derivative) in solid-phase peptide synthesis (SPPS), enabling the controlled construction of complex peptides and proteins. It is primarily utilized by pharmaceutical researchers, biotech companies, and fine chemical manufacturers engaged in the development of therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Pharmaceutical Intermediates: Key raw material for the synthesis of peptide-based active pharmaceutical ingredients (APIs).
• Biochemical Research: Used as a precursor in studies involving enzyme substrates, hormone analogs, and receptor ligands.
• Peptide Library Construction: Essential component for combinatorial chemistry and high-throughput screening to discover new bioactive compounds.
• Custom Peptide Synthesis: Provides a specific sequence fragment for contract research organizations (CROs) and CDMOs producing bespoke peptides.
• Proteomics & Diagnostics: Can be incorporated into labeled peptides used as internal standards in mass spectrometry or probes in assay development.

Basic Information

Product Name	Z-His-Tyr-Oh
CAS No.	17257-63-5
Molecular Formula	C₂₂H₂₄N₄O₆
Molecular Weight	440.45 g/mol
Synonyms	Z-His-Tyr-OH; Z-Histidyl-Tyrosine; N-Carbobenzoxy-L-histidyl-L-tyrosine; CBZ-L-Histidyl-L-Tyrosine; Nα-Cbz-L-histidyl-L-tyrosine; (S)-2-(((S)-1-((Benzyloxy)carbonyl)-1H-imidazol-4-yl)methyl)-2-amino-3-(4-hydroxyphenyl)propanoic acid; Z-His-Tyr; CBZ-His-Tyr-OH
EINECS	Contact for details

Quality Control

Our Z-His-Tyr-Oh is produced under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation (IR, MS), to ensure it meets the stringent requirements for peptide synthesis. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive). Allow the container to reach room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥97.0%
Optical Rotation	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	<20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.