Description

Ac-Phe-Nhme is a protected amino acid derivative, specifically N-Acetyl-L-phenylalanine methyl ester, widely utilized as a key chiral building block in organic synthesis. This compound is valued for its role in introducing the phenylalanine moiety while protecting both the amine and carboxylic acid functionalities, which is critical for the controlled synthesis of complex peptides and pharmaceutical intermediates. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors engaged in peptide synthesis and medicinal chemistry development.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the synthesis of peptide-based drugs and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Serves as a protected amino acid derivative in solid-phase and solution-phase peptide synthesis (SPPS).
• Biochemical Research: Used in proteomics research and as a standard or substrate in enzymatic studies.
• Fine Chemical Production: Employed in the custom synthesis of specialty chemicals, flavors, and fragrances.
• Academic & R&D: A valuable reagent for method development and exploring new synthetic pathways in university and industrial laboratories.

Basic Information

Product Name	Ac-Phe-Nhme
CAS No.	17186-60-6
Molecular Formula	C₁₂H₁₅NO₃
Molecular Weight	221.25 g/mol
Synonyms	N-Acetyl-L-phenylalanine methyl ester; Methyl N-acetyl-L-phenylalaninate; Ac-L-Phe-OMe; (S)-Methyl 2-acetamido-3-phenylpropanoate; N-Acetylphenylalanine methyl ester; L-Phenylalanine, N-acetyl-, methyl ester; NSC 334365; N-Acetyl-L-phenylalanine methyl ester
EINECS	Contact for details

Quality Control

Our Ac-Phe-Nhme is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation via IR and NMR spectroscopy. We provide full traceability and Certificates of Analysis (COA) are available for all shipments to ensure compliance with your research and production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-Isomer)
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	< 10 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.