Description

4-Chloropyrimidine is a versatile halogenated heterocyclic building block of significant importance in advanced organic synthesis. Its core value lies in its reactivity, where the chlorine atom serves as an excellent leaving group, enabling efficient nucleophilic aromatic substitution reactions to create complex molecular architectures. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of active pharmaceutical ingredients (APIs), intermediates, and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of various drug candidates, particularly those containing pyrimidine cores, such as kinase inhibitors and antiviral agents.
• Agrochemical Synthesis: Used in the development of herbicides, fungicides, and insecticides, where the pyrimidine ring is a common bioactive scaffold.
• Material Science Research: Serves as a building block for creating novel organic electronic materials, ligands for catalysis, and functional polymers.
• Chemical Biology & Proteomics: Employed in the design and synthesis of molecular probes, tags, and linkers for studying biological systems.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up processes under cGMP or ISO standards.
• Academic & R&D Laboratories: Used extensively in medicinal chemistry and synthetic methodology research for exploring new reaction pathways.

Basic Information

Product Name	4-Chloropyrimidine
CAS No.	17180-93-7
Molecular Formula	C4H3ClN2
Molecular Weight	114.53 g/mol
Synonyms	4-Chloropyrimidine; Pyrimidine, 4-chloro-; 4-Chloro-1,3-diazine; NSC 9375; 1,3-Diazine, 4-chloro-; 4-Chloro-pyrimidine; 4-Chloro-1,3-diazabenzene
EINECS	241-215-9

Quality Control

Our 4-Chloropyrimidine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, GC for residual solvents, and NMR/IR for structural confirmation, to ensure it meets the high standards required for research and industrial synthesis. A detailed Certificate of Analysis (COA) is provided with each shipment, and we support compliance with global regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be amber or opaque.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	64 - 68 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.