Description

S-Adenosyl-L-Methionine (SAMe) is a critical endogenous cofactor and methyl donor involved in numerous biochemical transmethylation, transsulfuration, and aminopropylation reactions. Its role is fundamental in supporting cellular function, making it a high-value compound for advanced research and pharmaceutical development. This product is essential for manufacturers and R&D teams in the pharmaceutical, nutraceutical, and life science sectors seeking a reliable source for high-purity biochemical intermediates.

Application

• Pharmaceutical Intermediates: Key starting material or active ingredient in the synthesis of prescription drugs targeting liver function, osteoarthritis, and neurological conditions.
• Dietary Supplements & Nutraceuticals: Formulated into capsules and tablets to support joint health, liver detoxification pathways, and mood regulation.
• Biochemical Research & Diagnostics: Utilized as a critical reagent in enzymatic assays, metabolic pathway studies, and epigenetics research focusing on methylation processes.
• Cell Culture & Media Supplements: Added to specialized cell culture media to support the growth and study of specific cell lines requiring methyl group donors.
• Veterinary Pharmaceuticals: Incorporated into therapeutic formulations for companion and livestock animals for similar hepatic and musculoskeletal support.

Basic Information

Product Name	S-Adenosyl-L-Methionine
CAS No.	17176-17-9
Molecular Formula	C15H22N6O5S+
Molecular Weight	398.44 g/mol
Synonyms	SAMe; SAM; AdoMet; Ademetionine; S-Adenosylmethionine; (3S)-5'-[(3S)-3-Amino-3-carboxypropyl]methylsulfonio]-5'-deoxyadenosine; L-S-Adenosylmethionine; Active Methionine
EINECS	241-207-5

Quality Control

Our S-Adenosyl-L-Methionine is manufactured under strict quality management systems. We offer material suitable for pharmaceutical and nutraceutical applications, with quality controls aligned with industry standards. A comprehensive Certificate of Analysis (COA) is provided with each batch, detailing purity, identity, and impurity profiles to ensure it meets your specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic and easily oxidized nature, store under an inert atmosphere (e.g., nitrogen or argon) at a controlled temperature of -20°C or below for long-term stability. For short-term use, store at 2-8°C. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Specific Rotation	+48° to +52° (c=1 in 0.1N HCl)
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Microbiological Analysis	Total Plate Count < 1000 CFU/g; Yeast & Mold < 100 CFU/g; Absence of E. coli, Salmonella

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.