Description

Nordimaprit is a selective histamine H2-receptor antagonist, a compound of significant interest in pharmacological research and development. Its primary value lies in its utility as a precise biochemical tool for studying histamine receptor subtypes and their physiological roles. This makes it essential for pharmaceutical companies, academic research institutions, and contract research organizations (CROs) focused on neuroscience, gastroenterology, and the development of novel therapeutic agents.

Application

• Pharmacological Research: A key reference standard and tool compound for investigating the function and distribution of histamine H2 receptors in various biological systems.
• Drug Discovery & Development: Used in high-throughput screening (HTS) assays and in vitro studies to identify and characterize new H2-receptor targeting molecules.
• Neuroscience Studies: Employed to elucidate the role of histaminergic signaling in the central nervous system, including studies on sleep-wake cycles, cognition, and appetite regulation.
• Gastrointestinal Research: Applied in models to study gastric acid secretion and the potential therapeutic effects of H2-receptor modulation.
• Biochemical Pathway Analysis: Serves as a selective antagonist to help map downstream signaling cascades activated by histamine H2 receptors.
• Reference Standard: Used for quality control, method development, and validation in analytical laboratories supporting pharmaceutical R&D.

Basic Information

Product Name	Nordimaprit
CAS No.	17124-82-2
Molecular Formula	C9H15N5S
Molecular Weight	225.31 g/mol
Synonyms	Nordimaprit; SK&F 92408; Nα-Guanylhistamine; 1-(4-Imidazolyl)-4-guanidinobutane; 4-Guanidino-N-(1H-imidazol-4-yl)butan-1-amine; Nω-Guanylhistamine; Histamine, Nω-guanyl-; Nω-Guanylhistamine dihydrochloride (salt form)
EINECS	Contact for details

Quality Control

Our Nordimaprit is produced under a strict quality management system to ensure batch-to-batch consistency and reliability for research applications. We provide comprehensive analytical data, including purity verification by HPLC and structural confirmation. A Certificate of Analysis (COA) detailing identity, purity, and related substances is supplied with each batch to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). For long-term storage, consider storing desiccated at -20°C. Handle and store in accordance with good laboratory practices.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.