Description

Nomega-Monomethyl-L-Arginine Acetate is a high-purity, chemically modified derivative of the amino acid L-arginine, specifically methylated at the ω-guanidino nitrogen. This compound serves as a critical biochemical tool and pharmaceutical intermediate, primarily valued for its role as a potent and selective inhibitor of nitric oxide synthase (NOS). It is essential for researchers and manufacturers in the life sciences sector who require precise, high-quality building blocks for drug discovery, biochemical research, and the development of therapeutic agents targeting cardiovascular and neurological pathways.

Application

• Nitric Oxide Synthase (NOS) Inhibition Research: A standard, high-purity reference compound for in vitro and in vivo studies investigating the role of nitric oxide in physiological and pathological processes.
• Pharmaceutical Intermediate: Used in the synthesis of more complex molecules targeting cardiovascular diseases, sepsis, and neurodegenerative disorders where NOS activity modulation is desired.
• Biochemical Reagent: Employed in enzyme kinetics studies, assay development, and as a control substance in high-throughput screening for drug discovery programs.
• Cell Culture & Molecular Biology: Applied in cell-based assays to study the effects of specific NOS inhibition on cell signaling, inflammation, and vascular function.
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development and validation in quality control laboratories.

Basic Information

Product Name	Nomega-Monomethyl-L-Arginine Acetate
CAS No.	17035-90-4
Molecular Formula	C9H19N5O2 • C2H4O2
Molecular Weight	291.32 g/mol (free base: 218.28 g/mol)
Synonyms	L-NMMA Acetate; NG-Monomethyl-L-arginine acetate; NG-Monomethyl-L-arginine acetate; Nω-Monomethyl-L-arginine acetate; MMA; L-NMMA; SD-6010; Nitric Oxide Synthase Inhibitor I; (S)-2-Amino-5-[(amino-methyl)amino]pentanoic acid acetate
EINECS	Contact for details

Quality Control

Our Nomega-Monomethyl-L-Arginine Acetate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and residual solvent screening, to ensure it meets the stringent requirements for research and pharmaceutical applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, confirming compliance with in-house specifications developed for high-purity biochemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Rotation	[α]D20: +22.0° to +26.0° (c=1 in H2O)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.