Description

H-Thr(Ac)-OH is a protected derivative of the amino acid threonine, specifically featuring an acetyl group on the hydroxyl side chain. This modification is crucial for preventing unwanted side reactions during complex peptide synthesis, ensuring high coupling efficiency and product purity. It is an essential building block for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing novel peptide-based therapeutics, diagnostics, and research reagents.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the controlled assembly of peptide chains in both Fmoc and Boc chemistry strategies.
• Pharmaceutical Intermediates: Serves as a critical intermediate in the production of active pharmaceutical ingredients (APIs) for peptide drugs, including hormones, antibiotics, and enzyme inhibitors.
• Bioconjugation & Labeling: Used in the site-specific modification of peptides and proteins, where the protected hydroxyl group allows for selective deprotection and subsequent conjugation with labels, dyes, or other functional molecules.
• Combinatorial Chemistry: Employed in libraries for drug discovery to generate diverse arrays of peptide-like compounds for high-throughput screening.
• Biochemical Research: A fundamental reagent for studying protein structure-function relationships, enzyme mechanisms, and metabolic pathways involving threonine.
• Glycopeptide Synthesis: Acts as a precursor for introducing O-linked glycosylation sites into synthetic peptides, mimicking natural post-translational modifications.

Basic Information

Product Name	H-Thr(Ac)-OH
CAS No.	17012-42-9
Molecular Formula	C6H11NO4
Molecular Weight	161.16 g/mol
Synonyms	N-Acetyl-O-acetyl-L-threonine; O-Acetyl-L-threonine; L-Threonine, O-acetate; Ac-Thr-OH; H-L-Thr(Ac)-OH; (2S,3R)-2-Amino-3-(acetyloxy)butanoic acid; Thr(Ac); Acetylthreonine
EINECS	Contact for details

Quality Control

Our H-Thr(Ac)-OH is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation via IR and NMR spectroscopy. We provide full traceability and a Certificate of Analysis (COA) with every shipment, ensuring compliance with the stringent requirements of pharmaceutical R&D and production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccated conditions to maintain stability and prevent hydrolysis of the acetyl protecting group.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation	[α]²⁰D: -15.0° to -18.0° (c=1 in H₂O)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.