Description

n-Benzyloxycarbonyl-L-Lysine Benzyl Ester p-Toluenesulfonate is a protected amino acid derivative, specifically a tosylate salt of a lysine derivative with orthogonal benzyloxycarbonyl (Z) and benzyl ester protecting groups. This compound is a critical building block in peptide synthesis, offering high purity and stability for the controlled elongation of peptide chains. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic peptides, APIs, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled incorporation of lysine residues into peptide sequences.
• Solution-Phase Peptide Synthesis: Used in classical solution methods for constructing complex peptides and small proteins.
• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of peptide-based Active Pharmaceutical Ingredients (APIs).
• Bioconjugation & Labeling: The reactive amine, when selectively deprotected, can be used for attaching labels, tags, or linker molecules.
• Research & Development: Essential for academic and industrial R&D focused on peptide chemistry, structure-activity relationships (SAR), and new drug discovery.
• Synthesis of Modified Amino Acids: Used to create custom, side-chain modified lysine analogs for specialized applications.

Basic Information

Product Name	n-Benzyloxycarbonyl-L-Lysine Benzyl Ester p-Toluenesulfonate
CAS No.	16964-83-3
Molecular Formula	C28H33N2O7S
Molecular Weight	541.64 g/mol
Synonyms	Z-Lys(Bzl)-OBzl p-Tosylate; Nα-Cbz-L-Lysine Benzyl Ester p-Toluenesulfonate; Nα-Z-L-Lysine Benzyl Ester Tosylate; Cbz-L-Lys(Bzl)-OH Benzyl Ester Tosylate Salt; Benzyl N6-[(benzyloxy)carbonyl]-N2-{[(benzyloxy)carbonyl]-L-lysinate} 4-methylbenzenesulfonate; Lysine, N2-[(phenylmethoxy)carbonyl]-, 1-(phenylmethyl) ester, (2S)-, 4-methylbenzenesulfonate (1:1); H-Lys(Z)-OBzl.TosOH
EINECS	Contact for details

Quality Control

Our n-Benzyloxycarbonyl-L-Lysine Benzyl Ester p-Toluenesulfonate is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles. We support compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation	[α]D20: Contact for details
Chiral Purity (HPLC)	≥99.0% (L-Isomer)
Loss on Drying	≤1.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.