Description

Dl-Propargylglycine CAS NO 16900-57-5 is a non-proteinogenic amino acid derivative featuring a reactive propargyl side chain. This compound serves as a versatile building block and a potent, irreversible inhibitor of specific enzymes, most notably cystathionine γ-lyase (CSE). It is essential for researchers and manufacturers in the pharmaceutical and life science sectors who require high-purity biochemical tools for metabolic pathway studies, drug discovery, and the development of novel therapeutic agents.

Application

• Biochemical Research: A critical tool for studying hydrogen sulfide (H₂S) biosynthesis pathways as a selective inhibitor of cystathionine γ-lyase (CSE).
• Pharmaceutical Intermediates: Serves as a key chiral synthon in the synthesis of more complex molecules for drug discovery programs.
• Enzyme Inhibition Studies: Used to investigate the role of CSE in various physiological and pathological processes, including cardiovascular function and inflammation.
• Metabolic Disorder Research: Applied in cellular and animal models to understand disorders related to transsulfuration pathway dysregulation.
• Peptide Chemistry: The propargyl group allows for click chemistry modifications, enabling the synthesis of labeled peptides or bioconjugates.
• Reference Standard: Used as an analytical standard in quality control laboratories for method development and validation.

Basic Information

Item	Details
Product Name	Dl-Propargylglycine
CAS No.	16900-57-5
Molecular Formula	C₅H₇NO₂
Molecular Weight	113.11 g/mol
Synonyms	DL-2-Amino-4-pentynoic acid; (±)-2-Amino-4-pentynoic acid; Propargylglycine; 2-Amino-4-pentynoic acid; NSC 56308; CSE Inhibitor; 4-Pentynoic acid, 2-amino-; Racemic propargylglycine
EINECS	Contact for details

Quality Control

Our Dl-Propargylglycine is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation (IR, NMR). We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or production specifications. Our quality commitment supports applications requiring high-purity biochemical reagents.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation or storage under an inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	Racemic mixture (DL)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.