Description

H-Thr-Phe-Oh is a high-purity dipeptide building block, specifically L-Threonyl-L-Phenylalanine. This compound is a critical intermediate for the synthesis of more complex peptides and peptidomimetics, offering precise control over molecular structure. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors developing novel therapeutic agents and biochemical tools.

Application

• Pharmaceutical Intermediate: Key building block for the solid-phase and solution-phase synthesis of therapeutic peptides and peptide hormones.
• Biochemical Research: Used as a standard or substrate in enzymatic studies, metabolic pathway analysis, and proteomics research.
• Peptidomimetic Development: Serves as a core structure for designing and synthesizing non-peptide compounds that mimic peptide activity.
• Cosmeceutical Ingredients: Potential precursor for bioactive peptides used in advanced skincare formulations targeting specific skin functions.
• Nutraceutical Synthesis: Intermediate in the production of specialized dietary supplements and functional food ingredients.
• Chemical Biology Probes: Incorporation into labeled peptides for cellular imaging, target identification, and drug discovery assays.

Basic Information

Product Name	H-Thr-Phe-Oh
CAS No.	16875-27-7
Molecular Formula	C13H18N2O4
Molecular Weight	266.29 g/mol
Synonyms	L-Threonyl-L-phenylalanine; Thr-Phe; T-F; H-L-Thr-L-Phe-OH; L-Thr-L-Phe; 2-[(2-Amino-3-hydroxybutanoyl)amino]-3-phenylpropanoic acid; (2S,3S)-2-[[(2S)-2-Amino-3-phenylpropanoyl]amino]-3-hydroxybutanoic acid; H-Thr-Phe-OH dipeptide
EINECS	Contact for details

Quality Control

Our H-Thr-Phe-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation by mass spectrometry and IR spectroscopy. Certificates of Analysis (COA) with detailed chromatograms are provided to ensure compliance with your research and cGMP-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This product is hygroscopic (moisture-sensitive). Allow the sealed container to reach room temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Optical Rotation	-20° to -25° (c=1 in H2O)
Chiral Purity (HPLC)	≥ 99.0% (L,L-isomer)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.