Description

Prolyl-Prolyl-Glycine is a synthetic tripeptide composed of two proline residues and one glycine residue. This compound is of significant interest in biochemical and pharmaceutical research due to its role as a specific sequence motif and its potential influence on protein structure and stability. It serves as a valuable building block and reference standard for researchers in peptide synthesis, enzymology, and drug discovery. Industries requiring high-purity peptide intermediates for advanced R&D will find this product essential for their development pipelines.

Application

• Biochemical Research: Used as a model substrate or inhibitor in studies of proline-specific enzymes like prolyl oligopeptidase and dipeptidyl peptidase IV.
• Pharmaceutical Development: Serves as a key intermediate or reference standard in the synthesis of novel therapeutic peptides and peptidomimetics.
• Cosmeceutical Formulations: Investigated for potential applications in anti-aging and skin repair products due to its collagen-related peptide sequence.
• Nutritional Science: Studied for its potential bioactivity and role as a metabolic intermediate or biomarker.
• Academic & Institutional R&D: A fundamental reagent for universities and research institutes exploring peptide chemistry, protein folding, and molecular biology.
• Quality Control & Analytical Standards: Employed as a high-purity standard for method development and validation in analytical laboratories (HPLC, MS).

Basic Information

Product Name	Prolyl-Prolyl-Glycine
CAS No.	16875-10-8
Molecular Formula	C12H19N3O4
Molecular Weight	269.30 g/mol
Synonyms	PPG; H-Pro-Pro-Gly-OH; Pro-Pro-Gly; L-Prolyl-L-prolylglycine; (S)-2-((S)-Pyrrolidine-2-carboxamido)-N-(carboxymethyl)pyrrolidine-1-carboxamide; Glycine, L-prolyl-L-prolyl-; Tripeptide P-P-G
EINECS	240-896-5

Quality Control

Our Prolyl-Prolyl-Glycine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and residual solvent screening, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We can supply material compliant with various pharmacopeial standards (e.g., USP reference standards) upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Optical Rotation	-75° to -85° (c=1 in H2O)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.