Description

Cyclo(-Glu-Glu) CAS NO 16691-00-2 is a cyclic dipeptide composed of two glutamic acid residues, also known as a diketopiperazine (DKP). This compound is of significant interest in pharmaceutical research and development due to its role as a potential metabolite, impurity, or synthetic intermediate in peptide-based drugs. It serves as a critical reference standard and building block for researchers and manufacturers in the life sciences sector, particularly those focused on peptide chemistry, analytical method development, and quality control.

Application

• Pharmaceutical Reference Standard: Used for the identification, qualification, and quantification of related substances in peptide Active Pharmaceutical Ingredients (APIs) and finished drug products.
• Peptide Synthesis Intermediate: Acts as a specialized building block or a protected form in the solid-phase or solution-phase synthesis of more complex peptides and peptidomimetics.
• Metabolite & Impurity Studies: Employed in analytical research to study the stability, degradation pathways, and metabolic profiles of therapeutic peptides containing glutamic acid.
• Biochemical Research: Utilized as a model compound to study the structure, stability, and biological activity of cyclic peptides and diketopiperazines.
• Quality Control & Assurance: Essential for developing and validating analytical methods (e.g., HPLC, LC-MS) to ensure the purity and safety of peptide-based pharmaceuticals.
• Cosmetic & Dermatological Research: Investigated for potential bioactivity in skincare formulations due to the properties of peptide derivatives.

Basic Information

Product Name	Cyclo(-Glu-Glu)
CAS No.	16691-00-2
Molecular Formula	C10H14N2O6
Molecular Weight	258.23 g/mol
Synonyms	Cyclo(L-glutamyl-L-glutamic acid); (3S,6S)-3,6-Bis(2-carboxyethyl)-2,5-piperazinedione; L-Glutamic acid, cyclic anhydride dimer; Cyclo(Glu-Glu); Diketopiperazine of L-glutamic acid; c(Glu-Glu); (S,S)-Cyclo(glutamylglutamic acid); Glutamic acid diketopiperazine
EINECS	Contact for details

Quality Control

Our Cyclo(-Glu-Glu) is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to maintain stability and purity. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.