Description

Nalpha-Methylhistamine Dihydrochloride is a high-purity, biologically active derivative of histamine, specifically designed for research and development applications. This compound serves as a critical tool for investigating the histamine H3 receptor, playing a pivotal role in neurological and immunological studies. It is essential for pharmaceutical R&D laboratories, academic research institutions, and diagnostic manufacturers focused on neuropharmacology and inflammation pathways. The product is supplied with a guaranteed Certificate of Analysis to ensure batch-to-batch consistency and reliability for sensitive experimental work.

Application

• Pharmacological Research: A key reference standard and active pharmaceutical ingredient (API) intermediate in the study of histamine H3 receptor agonists and antagonists.
• Neuroscience Studies: Used in vitro and in vivo models to explore the role of histaminergic systems in sleep-wake cycles, cognition, and neuroinflammatory responses.
• Biochemical Assay Development: Serves as a precise calibrant and substrate in the development of high-throughput screening (HTS) assays and ELISA kits targeting histamine pathways.
• Drug Discovery & Development: Employed as a building block in the synthesis of novel therapeutic candidates for disorders of the central nervous system.
• Academic & Institutional Research: Provides a reliable reagent for fundamental research into G-protein-coupled receptor (GPCR) signaling and mediator release studies.

Basic Information

Product Name	Nalpha-Methylhistamine Dihydrochloride
CAS No.	16503-22-3
Molecular Formula	C7H13N3·2HCl
Molecular Weight	224.12 g/mol
Synonyms	N(alpha)-Methylhistamine Dihydrochloride; Nα-Methylhistamine 2HCl; 1-Methyl-4-(2-aminoethyl)imidazole Dihydrochloride; N(τ)-Methylhistamine Dihydrochloride; (2-(1-Methyl-1H-imidazol-4-yl)ethyl)amine Dihydrochloride; N-α-Methylhistamine 2HCl; Nα-MeHA·2HCl
EINECS	Contact for details

Quality Control

Every batch of Nalpha-Methylhistamine Dihydrochloride is manufactured under a strict quality management system and undergoes comprehensive analytical testing. Our products are guaranteed to meet high-purity standards suitable for research applications, with specifications typically exceeding 98.0% purity (by HPLC). A detailed Certificate of Analysis (COA) documenting identity, purity, and impurity profiles is provided with each shipment to ensure full traceability and compliance with your research protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.