Description

4-Chloro-6-Fluoroquinazoline is a high-value, multi-functional heterocyclic building block essential for advanced organic synthesis. This compound matters for its role as a key precursor in the development of targeted small-molecule pharmaceuticals, particularly kinase inhibitors. Pharmaceutical R&D laboratories and fine chemical manufacturers need it to construct complex molecular architectures for drug discovery programs and the production of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A critical scaffold in the synthesis of tyrosine kinase inhibitors and other targeted cancer therapeutics.
• Chemical Research & Development: Serves as a versatile building block for constructing novel quinazoline-based libraries for biological screening.
• Agrochemical Synthesis: Used in the research and development of new herbicides and fungicides containing the quinazoline moiety.
• Material Science Precursor: Potential intermediate in the synthesis of organic electronic materials and advanced polymers.

Basic Information

Item	Detail
Product Name	4-Chloro-6-Fluoroquinazoline
CAS No.	16499-61-9
Molecular Formula	C8H4ClFN2
Molecular Weight	182.58 g/mol
Synonyms	6-Fluoro-4-chloroquinazoline; 4-Chloro-6-fluoro-quinazoline; Quinazoline, 4-chloro-6-fluoro-; 16499-61-9; 4-Chlor-6-fluorchinazolin (German); 4-クロロ-6-フルオロキナゾリン (Japanese)
EINECS	Contact for details

Quality Control

Our 4-Chloro-6-Fluoroquinazoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.