Description

4-Chloro-5-Fluoroquinazoline is a high-value, multi-functional heterocyclic building block essential for modern synthetic chemistry. This compound serves as a critical intermediate in the development of targeted pharmaceutical agents, particularly kinase inhibitors used in oncology and other therapeutic areas. It is primarily sought by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the synthesis of novel active pharmaceutical ingredients (APIs) and advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of tyrosine kinase inhibitors (TKIs) and other small-molecule drugs targeting cancer pathways.
• Agrochemical Research: Used in the development of new herbicides and fungicides, leveraging its quinazoline core for biological activity.
• Material Science: Serves as a building block for organic electronic materials, such as OLEDs and semiconductors, due to its electron-deficient aromatic structure.
• Chemical Biology & Proteomics: Employed in the design of chemical probes and affinity tags to study enzyme function and protein interactions.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses producing complex molecules for client-specific projects.
• Academic Research: Used in universities and research institutes for methodological studies in heterocyclic and medicinal chemistry.

Basic Information

Product Name	4-Chloro-5-Fluoroquinazoline
CAS No.	16499-60-8
Molecular Formula	C8H4ClFN2
Molecular Weight	182.58 g/mol
Synonyms	5-Fluoro-4-chloroquinazoline; Quinazoline, 4-chloro-5-fluoro-; 4-Chloro-5-fluoro-quinazoline; 16499-60-8; 4-Chloro-5-fluoroquinazoline; 5-Fluoro-4-chloro-quinazoline
EINECS	Contact for details

Quality Control

Our 4-Chloro-5-Fluoroquinazoline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. We provide full traceability and detailed Certificates of Analysis (COA) with every shipment, supporting your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.