Description

Quinazoline, 5-Fluoro- (8Ci) CAS NO 16499-43-7 is a specialized fluorinated heterocyclic compound that serves as a crucial building block in advanced organic synthesis. Its value lies in the strategic introduction of a fluorine atom onto the quinazoline core, enabling the fine-tuning of electronic properties, metabolic stability, and binding affinity in target molecules. This high-purity intermediate is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly those focused on discovering new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, especially kinase inhibitors, anticancer agents, and central nervous system (CNS) active compounds.
• Agrochemical Research: Used in the synthesis of advanced herbicides, fungicides, and pesticides, where the fluorine atom can enhance biological activity and environmental persistence.
• Material Science Precursor: Serves as a starting material for creating functionalized organic ligands and fluorinated molecules used in organic light-emitting diodes (OLEDs) and other electronic materials.
• Academic & Contract Research: Employed in university and CRO laboratories for methodological studies in fluorination chemistry and heterocyclic compound synthesis.
• Chemical Biology Probe Development: Utilized to create fluorescent tags or molecular probes for studying biological processes and enzyme mechanisms.

Basic Information

Product Name	Quinazoline, 5-Fluoro- (8Ci)
CAS No.	16499-43-7
Molecular Formula	C8H5FN2
Molecular Weight	148.14 g/mol
Synonyms	5-Fluoroquinazoline; 5-Fluoro-1,3-diazanaphthalene; Quinazoline, 5-fluoro-; 5-Fluoro-benzo[d]pyrimidine; 5-Fluorquinazolin; 16499-43-7 (CAS); 5-Fluoro-quinazoline; Fluorinated quinazoline derivative
EINECS	Contact for details

Quality Control

Our Quinazoline, 5-Fluoro- (8Ci) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.