Description

D -(+)-Threo -β-Hydroxyaspartic Acid is a high-purity, non-proteinogenic amino acid derivative of significant interest in biochemical research and pharmaceutical development. Its unique stereochemistry and functional groups make it a valuable chiral building block and a key intermediate in the synthesis of complex molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors who require high-quality, well-characterized intermediates for drug discovery, peptide synthesis, and enzyme studies.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of enzyme inhibitors and receptor antagonists.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, especially those involving aspartate aminotransferases and other enzymes in amino acid metabolism.
• Peptide Synthesis: Incorporated into synthetic peptides to introduce conformational constraints or specific biological activity, serving as a non-natural amino acid residue.
• Neurology Research: Investigated for its role as a potential modulator of glutamate receptors (e.g., NMDA receptors) in neurological studies.
• Fine Chemical Synthesis: Employed as a versatile building block for the asymmetric synthesis of complex natural products and specialty chemicals.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical and research laboratories.

Basic Information

Product Name	D -(+)-Threo -β-Hydroxyaspartic Acid
CAS No.	16417-36-0
Molecular Formula	C4H7NO5
Molecular Weight	149.10 g/mol
Synonyms	(2R,3S)-2-Amino-3-hydroxybutanedioic acid; D-threo-β-Hydroxyaspartic acid; (2R,3S)-3-Hydroxyaspartic acid; D-erythro-β-Hydroxyaspartate; H-Asp(OH)-OH; β-Hydroxy-D-aspartic acid; 3-Hydroxy-D-aspartic acid; D-β-Hydroxyaspartate
EINECS	Contact for details

Quality Control

Our D -(+)-Threo -β-Hydroxyaspartic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and specific tests is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. For long-term storage, consider desiccated or inert atmosphere packaging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% de (D-threo isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.