Description

Z-Gly-Leu-Gly-Oh is a protected tripeptide derivative, specifically a benzyloxycarbonyl (Z)-protected glycine-leucine-glycine sequence with a free carboxylic acid terminus. This compound serves as a crucial building block in solid-phase peptide synthesis (SPPS) and other advanced chemical syntheses, offering precise control over peptide chain elongation. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and fine chemical manufacturers engaged in the development of therapeutic peptides, biochemical probes, and complex organic molecules.

Application

• Pharmaceutical Intermediate: Key raw material for the synthesis of longer, more complex therapeutic peptide sequences.
• Biochemical Research: Used as a standard or reagent in enzymatic studies, substrate specificity assays, and proteomics research.
• Solid-Phase Peptide Synthesis (SPPS): Acts as a protected fragment for convergent peptide synthesis strategies, enabling efficient chain assembly.
• Organic Synthesis Building Block: Employed in the construction of peptidomimetics and other non-natural bioactive compounds.
• Custom Peptide Service: A fundamental component for contract research and manufacturing organizations (CROs/CMOs) offering bespoke peptide production.

Basic Information

Product Name	Z-Gly-Leu-Gly-Oh
CAS No.	16295-38-8
Molecular Formula	C19H27N3O6
Molecular Weight	393.44 g/mol
Synonyms	Z-Gly-Leu-Gly-OH; N-Benzyloxycarbonyl-glycyl-L-leucyl-glycine; N-Cbz-Glycyl-L-leucyl-glycine; Cbz-Gly-Leu-Gly-OH; Benzyloxycarbonyl-Gly-Leu-Gly; N-Carbobenzoxy-glycyl-leucyl-glycine; Glycine, N-[(benzyloxy)carbonyl]glycyl-L-leucyl-; Z-Gly-L-Leu-Gly-OH
EINECS	Contact for details

Quality Control

Our Z-Gly-Leu-Gly-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm enantiomeric integrity, and spectroscopic identification (NMR, MS). Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive); keep the original container tightly sealed in a desiccated environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Specific Rotation	-20° to -25° (c=1 in DMF)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.