Description

4-Desmethoxy-4-Bromo Trimethoprim is a key brominated derivative and synthetic intermediate of the antibiotic Trimethoprim. This compound is of significant value in pharmaceutical research and development, particularly for the synthesis of novel antibacterial agents and for structure-activity relationship (SAR) studies. It is primarily utilized by research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers focused on developing advanced antimicrobial compounds and exploring chemical modifications to existing drug scaffolds.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel Trimethoprim analogs and next-generation dihydrofolate reductase (DHFR) inhibitors.
• Antibacterial Research: Used in medicinal chemistry to study the impact of halogen substitution on the antibacterial activity and pharmacokinetic properties of folate antagonists.
• Chemical Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Process Chemistry: Employed in route scouting and optimization for the scalable production of specialized antibacterial agents.
• Academic Research: Utilized in university and institutional labs for biochemical studies targeting bacterial enzyme inhibition.

Basic Information

Product Name	4-Desmethoxy-4-Bromo Trimethoprim
CAS No.	16285-82-8
Molecular Formula	C13H15BrN4O3
Molecular Weight	355.19 g/mol
Synonyms	4-Bromo-2,4-diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine; 4-Bromo Trimethoprim Derivative; 4-Bromo-TMP; 4-Bromo-5-[(3,4,5-trimethoxyphenyl)methyl]-2,4-pyrimidinediamine; 2,4-Diamino-5-(3,4,5-trimethoxybenzyl)-4-bromopyrimidine; 4-Bromo-2,4-diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine
EINECS	Contact for details

Quality Control

Our 4-Desmethoxy-4-Bromo Trimethoprim is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for research and synthesis applications. We provide comprehensive analytical documentation, including Certificates of Analysis (COA) with detailed results from HPLC, NMR, and mass spectrometry. Our quality system is designed to meet the stringent requirements of pharmaceutical R&D and fine chemical production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.