Description

L-Proline, 4-Amino-, (4R)- (9Ci) CAS NO 16257-88-8 is a high-purity, non-proteinogenic amino acid derivative of proline, characterized by an additional amino group at the 4-position of the pyrrolidine ring. This specific stereochemistry and functionalization make it a valuable chiral building block and intermediate in advanced organic synthesis. It is primarily sought after by research institutions and manufacturers in the pharmaceutical and biotechnology sectors for applications in peptide chemistry, drug discovery, and the development of novel bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug candidates, particularly peptidomimetics and protease inhibitors.
• Peptide Research & Synthesis: Used to incorporate modified proline residues into synthetic peptides to study structure-activity relationships and enhance metabolic stability.
• Bioconjugation & Probe Development: Serves as a functional handle for creating labeled compounds or conjugates in chemical biology and diagnostic applications.
• Asymmetric Catalysis: Employed as a precursor or ligand in the development of chiral catalysts for stereoselective transformations.
• Biochemical Research: Utilized in enzymatic studies and as a substrate or inhibitor for amino acid-metabolizing enzymes.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	L-Proline, 4-Amino-, (4R)- (9Ci)
CAS No.	16257-88-8
Molecular Formula	C5H10N2O2
Molecular Weight	130.15 g/mol
Synonyms	(2S,4R)-4-Aminopyrrolidine-2-carboxylic Acid; (4R)-4-Aminoproline; L-4-Aminoproline; cis-4-Amino-L-proline; 4-Azaproline; 4-Amino-L-proline; 4-Aminoproline; (4R)-4-Amino-L-proline
EINECS	Contact for details

Quality Control

Our L-Proline, 4-Amino-, (4R)- (9Ci) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, to ensure it meets exacting standards for research and synthesis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and specific impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.