Description

D-Carnitine Hydrochloride is the hydrochloride salt of the D-isomer of carnitine, a naturally occurring amino acid derivative. This high-purity enantiomer is critical for research and development applications where stereochemical specificity is required, serving as a key reference standard and chiral building block. It is primarily utilized by pharmaceutical R&D laboratories, analytical chemistry service providers, and manufacturers of fine chemicals and dietary supplements for method development, quality control, and metabolic studies.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the identification, assay, and impurity profiling of L-carnitine and related substances in pharmacopeial testing (USP, EP).
• Chiral Intermediate: Serves as a starting material or intermediate in the synthesis of more complex chiral molecules for pharmaceutical research.
• Metabolic Research: Employed in biochemical and pharmacological studies to investigate the specific biological role and transport mechanisms of the D-enantiomer versus the active L-form.
• Analytical Method Development: Essential for developing and validating stereospecific analytical methods, such as chiral HPLC or capillary electrophoresis, to separate and quantify carnitine isomers.
• Dietary Supplement Analysis: Acts as a critical standard in quality control laboratories to ensure the absence of the inactive D-isomer in L-carnitine supplement raw materials and finished products.
• Fine Chemical Synthesis: Utilized in organic synthesis for introducing the carnitine moiety or for studying stereoselective reactions.

Basic Information

Product Name	D-Carnitine Hydrochloride
CAS No.	16224-32-1
Molecular Formula	C7H15NO3 • HCl
Molecular Weight	197.66 g/mol (Free base: 161.20)
Synonyms	(R)-Carnitine Hydrochloride; D-(-)-Carnitine Hydrochloride; (R)-3-Carboxy-2-hydroxy-N,N,N-trimethyl-1-propanaminium Chloride; (R)-3-Hydroxy-4-(trimethylammonio)butyrate Hydrochloride; D-O-Carnitine HCl; Vitamin Bt (D-form) Hydrochloride; Levocarnitine (D-enantiomer) Hydrochloride
EINECS	240-299-3

Quality Control

Our D-Carnitine Hydrochloride is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity assay, to ensure it meets stringent specifications for research and standard applications. A detailed Certificate of Analysis (COA) providing results for identity, purity (HPLC), optical rotation, residue on ignition, and heavy metals is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive). For long-term storage, consider desiccated conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (Optical Rotation)	[α]20/D: -20° to -24° (c=1 in H2O)
Assay (HPLC)	≥98.0% (on anhydrous basis)
Chiral Purity (HPLC)	≥99.0% D-isomer
Water (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.