Description

4-Hydroxy-2-(Methylthio)-6-(Trifluoromethyl)Pyrimidine is a high-value, fluorinated pyrimidine derivative that serves as a critical synthetic intermediate in advanced chemical manufacturing. This compound matters for its unique trifluoromethyl and methylthio functional groups, which are pivotal for imparting desirable properties like metabolic stability and lipophilicity in target molecules. It is primarily needed by research and development chemists and process engineers in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and anti-infective applications.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Material Science Research: Employed in the development of specialty chemicals, liquid crystals, and advanced polymers requiring specific fluorine-containing motifs.
• Chemical Biology & Proteomics: Acts as a versatile scaffold or labeling agent in the design of molecular probes and enzyme inhibitors for biochemical research.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in bespoke synthesis projects and scale-up campaigns.

Basic Information

Product Name	4-Hydroxy-2-(Methylthio)-6-(Trifluoromethyl)Pyrimidine
CAS No.	16097-62-4
Molecular Formula	C6H5F3N2OS
Molecular Weight	210.18 g/mol
Synonyms	6-(Trifluoromethyl)-2-methylsulfanyl-1H-pyrimidin-4-one; 2-(Methylthio)-4-hydroxy-6-(trifluoromethyl)pyrimidine; 4-Hydroxy-2-methylthio-6-trifluoromethylpyrimidine; 4-Hydroxy-2-methylmercapto-6-trifluoromethylpyrimidine; 2-Methylmercapto-4-hydroxy-6-trifluoromethylpyrimidine; 6-Trifluoromethyl-2-methylmercapto-4-pyrimidinol; 16097-62-4; 4(1H)-Pyrimidinone, 2-(methylthio)-6-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 4-Hydroxy-2-(Methylthio)-6-(Trifluoromethyl)Pyrimidine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply and traceability for critical R&D and production applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere if necessary. Keep away from strong acids, strong bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.