Description

Z-D-Phe-Phe-Arg(No2)-Oh is a synthetic tripeptide derivative featuring a nitro-substituted arginine residue. This compound is a key intermediate and a potent, selective inhibitor of thrombin and related serine proteases, making it valuable for biochemical research and pharmaceutical development. It is primarily utilized by research institutions and pharmaceutical companies engaged in the study of blood coagulation, thrombosis, and the development of novel antithrombotic agents.

Application

• Biochemical Research: As a standard inhibitor in enzymatic assays to study the kinetics and inhibition mechanisms of thrombin, trypsin, and other trypsin-like serine proteases.
• Pharmaceutical R&D: Serves as a critical reference compound and building block in the discovery and development of new anticoagulant and antithrombotic drugs.
• Diagnostic Reagent Development: Used in the formulation of specialized diagnostic kits for measuring coagulation factors and protease activity in clinical laboratories.
• Protease Specificity Studies: Employed to investigate the substrate specificity and active site characteristics of various proteolytic enzymes.

Basic Information

Product Name	Z-D-Phe-Phe-Arg(No2)-Oh
CAS No.	16088-35-0
Molecular Formula	C35H41N7O8
Molecular Weight	687.75 g/mol
Synonyms	Z-D-Phe-Phe-Arg(NO2)-OH; Benzyloxycarbonyl-D-phenylalanyl-L-phenylalanyl-NG-nitro-L-arginine; D-Phe-Phe-Arg(NO2)-OH, Z-; Thrombin Inhibitor I; H-D-Phe-Phe-Arg(NO2)-OH, Z-; Z-D-Phenylalanyl-L-phenylalanyl-Nω-nitro-L-arginine; Nα-Carbobenzoxy-D-phenylalanyl-L-phenylalanyl-NG-nitro-L-arginine
EINECS	Contact for details

Quality Control

Our Z-D-Phe-Phe-Arg(No2)-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and specific tests for residual solvents and moisture content. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.