Description

Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe is a synthetic octapeptide sequence, also known as Bradykinin Potentiating Peptide 5a (BPP-5a). This compound is of significant interest in biochemical and pharmaceutical research due to its role as a potent inhibitor of the angiotensin-converting enzyme (ACE), influencing blood pressure regulation. It is primarily utilized by research institutions, pharmaceutical developers, and biotechnology companies engaged in cardiovascular research, drug discovery, and the study of peptide-based therapeutics.

Application

• Biomedical Research: A key tool for studying the renin-angiotensin system, hypertension mechanisms, and ACE inhibition pathways.
• Pharmaceutical Development: Serves as a reference standard and a lead compound in the discovery of novel antihypertensive and cardiovascular drugs.
• Biochemical Assays: Used in in vitro enzymatic assays to measure and characterize ACE activity and inhibition.
• Peptide Chemistry Studies: Employed in research focusing on peptide synthesis, structure-activity relationships (SAR), and stability.
• Academic Research: Utilized in university and institutional labs for pharmacological and physiological studies.

Basic Information

Product Name	Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe
CAS No.	15958-92-6
Molecular Formula	C44H62N12O10
Molecular Weight	918.04 g/mol
Synonyms	Bradykinin Potentiating Peptide 5a; BPP-5a; BPP5a; Pyr-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe; Pyr-RPPGFSPF; ACE Inhibitory Peptide; Angiotensin I-Converting Enzyme Inhibitor Peptide; Octapeptide RPPGFSPF; L-Arginyl-L-prolyl-L-prolylglycyl-L-phenylalanyl-L-seryl-L-prolyl-L-phenylalanine
EINECS	Contact for details

Quality Control

Our Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and amino acid analysis. A Certificate of Analysis (COA) detailing purity, related substances, and other critical parameters is provided with every shipment to ensure traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 5.0%
Amino Acid Composition	Conforms to theoretical values
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.