Description

H-D-Leu-Nh2 CAS NO 15893-47-7 is a high-purity, non-natural amino acid derivative, specifically the amide of D-Leucine. This chiral building block is essential for the synthesis of complex peptides and active pharmaceutical ingredients (APIs) where precise stereochemistry is critical. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for drug discovery and development.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of peptide-based drugs and novel therapeutic compounds.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to introduce the D-leucine residue, influencing peptide conformation and stability.
• Proteomics Research: Serves as a standard or building block in biochemical research for studying enzyme specificity and protein structure-function relationships.
• Asymmetric Synthesis: Employed as a chiral auxiliary or precursor in catalytic asymmetric reactions to create enantiomerically pure molecules.
• Bioconjugation: Can be used to modify biomolecules, creating conjugates for diagnostic or targeted drug delivery applications.
• Food & Flavor Chemistry: Potential use in the synthesis of specialized flavoring agents or nutritional supplements.

Basic Information

Product Name	H-D-Leu-Nh2
CAS No.	15893-47-7
Molecular Formula	C6H14N2O
Molecular Weight	130.19 g/mol
Synonyms	D-Leucinamide; (R)-2-Amino-4-methylpentanamide; D-2-Amino-4-methylvaleramide; H-D-Leu-NH2; D-Leu-NH2; (R)-Leucinamide; D-Leu Amide; UNII-9P6H8B6U4P
EINECS	Contact for details

Quality Control

Our H-D-Leu-Nh2 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets stringent specifications for pharmaceutical and research applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and compliance with relevant standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee (D-isomer)
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.