Description

Ac-Nle-OH is a high-purity, protected amino acid derivative, specifically N-Acetyl-L-norleucine. This compound serves as a critical building block in peptide synthesis and pharmaceutical research, offering a chemically stable, non-natural amino acid side chain for structure-activity relationship (SAR) studies. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors who require reliable, high-quality intermediates for drug discovery and development.

Application

• Peptide Synthesis: A key protected amino acid building block (Nle) for solid-phase and solution-phase peptide synthesis.
• Pharmaceutical Intermediates: Used in the research and development of novel therapeutic peptides and peptidomimetics.
• Structure-Activity Relationship (SAR) Studies: Incorporates a non-natural, hydrophobic side chain to modulate the properties and biological activity of peptide leads.
• Biochemical Research: Employed as a standard or reagent in enzymatic studies and metabolic pathway investigations.
• Fine Chemical Production: Serves as a specialized intermediate for the synthesis of complex organic molecules and custom compounds.

Basic Information

Product Name	Ac-Nle-OH
CAS No.	15891-49-3
Molecular Formula	C8H15NO3
Molecular Weight	173.21 g/mol
Synonyms	N-Acetyl-L-norleucine; N-Acetylnorleucine; (S)-2-Acetamidohexanoic acid; Ac-Nle; N-Acetyl-L-2-aminohexanoic acid; L-Norleucine, N-acetyl-; Ac-Nle-OH; N-Acetylnorleucine, L-
EINECS	Contact for details

Quality Control

Our Ac-Nle-OH is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral analysis to ensure enantiomeric integrity, meeting the exacting standards required for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) is provided with every shipment to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation	-15.0° to -20.0° (c=1 in AcOH)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.