Description

4-Hydroxymethylphenylalanine is a non-natural aromatic amino acid derivative featuring a hydroxymethyl functional group on the phenyl ring. This structural motif makes it a valuable chiral building block and intermediate in advanced organic synthesis, particularly for the development of novel pharmaceuticals and bioactive compounds. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for applications in peptide synthesis and medicinal chemistry.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, especially in peptide-based therapeutics.
• Peptide Synthesis: Used as a modified amino acid building block in solid-phase and solution-phase peptide synthesis to introduce specific functional properties.
• Medicinal Chemistry Research: Serves as a precursor or scaffold for creating compound libraries in structure-activity relationship (SAR) studies.
• Bioconjugation: The hydroxymethyl group can be functionalized for linking peptides or drugs to other molecules, carriers, or surfaces.
• Enzyme Inhibitor Development: Potential use in designing inhibitors that target enzymes recognizing phenylalanine derivatives.
• Fine Chemical Synthesis: An intermediate in the multi-step synthesis of complex organic molecules for various high-value applications.

Basic Information

Product Name	4-Hydroxymethylphenylalanine
CAS No.	15742-88-8
Molecular Formula	C10H13NO4
Molecular Weight	211.21 g/mol
Synonyms	4-(Hydroxymethyl)-L-phenylalanine; L-4-Hydroxymethylphenylalanine; (2S)-2-Amino-3-[4-(hydroxymethyl)phenyl]propanoic acid; HMPhe; 4-Hydroxybenzylglycine derivative; Fmoc-4-(hydroxymethyl)-L-phenylalanine (protected form); 4-Carbinoylphenylalanine; p-Hydroxymethylphenylalanine
EINECS	Contact for details

Quality Control

Our 4-Hydroxymethylphenylalanine is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the high standards required for research and synthesis applications. A Certificate of Analysis (COA) detailing specific results for identity, purity, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed in a dry environment to prevent absorption of atmospheric moisture, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.